Palestinian gunmen opened fire at a petrol station in the central West Bank on Tuesday, killing four Israelis and wounding four others.
The IDF reported that at least two gunmen carried out the attack near the settlement of Eli.
One of the terrorists was shot dead at the scene, while a second fled.
“IDF forces have begun a pursuit of additional suspects”, the military said.
Emergency services reported that eight Israelis were treated at the scene of the attack, at which four were declared dead.
Local residents were ordered to remain in their homes and lock their doors and windows until further notice, as troops scan the area.
The attack came just hours after a gun battle between Israeli troops and Palestinian terrorists in Jenin, killing 6 Palestinians, as well as a roadside bomb detonated near an army vehicle.
Eight IDF soldiers were wounded in the clashes and by the bomb.
So far this year, Palestinian terror attacks in Israel and the West Bank have killed 24 people, with several more seriously hurt, including today’s attack in Eli.
This morning also saw a suspected car ramming attack at a checkpoint in the northern West Bank.
Tensions between Israeli forces and Palestinians in the West Bank have been heightened in this period, with the IDF carrying out counter-terror night raids.